RRX Pharma Assay
It seems nearly every drug molecule works through a structural
interaction with a "target" or "receptor" molecule, or
protein that plays key roles in upstream, or downstream biological pathway
processes.
Notably, one might wish only to modulate a target protein function,
possibly by finding partner proteins, as suitable drug targets.
In the most
common model for this interaction the drug molecule inserts itself, into
a functionally important crevice, or pocket of its target protein somewhat
like a key in a lock.
The molecule then binds there and either induces
or, possibly more commonly, inhibits the protein's normal function in a pathway.
This apparently universal drug-target scheme enables a powerful approach
to drug discovery, starting with identification of the appropriate protein
target(s) for a given therapeutic need.
If enough is known about the distinguishing
structure of a target, it is theoretically feasible to design the structure
of an ideal preliminary small molecule drug, to interact with it.
This approach
offers the promise of eliminating much of the expensive inefficiency, of
conventional drug discovery.
Recently RRX Pharma has adopted
a novel approach for drug discovery that exploits the dynamic three-dimensional
geometry of molecular targets.
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